Yes you can make a secure file upload system for your clients to send you (large) files.

Only secure file-extensions can  be uploaded.

There are multiple ways to achieve this, just a public upload page or a special page for a client that uploads files multiple times.

Create a special upload directory for your client so he can manage his own uploaded files.

You can integrate this in to your existing website or use it as a stand alone application.

Very handy for print & advertising agencies or other businesses that need a solution to frequently receive (large) files from their clients.